MicroRNA-29a induces apoptosis via increasing the Bax:Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis

Abstract excerpt

The most prominent feature of systemic sclerosis (SSc) and other diseases associated with fibrosis is the prolonged activation of fibroblasts not eliminated by apoptosis, hence characterized by accumulation of more extra cellular matrix (ECM). We tend to verify if microRNA-29a (miR-29a) as an anti-fibrotic factor could induce apoptosis in SSc fibroblasts. We did not detect apoptosis in SSc fibroblasts. We found...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Dermatologic Treatments and Research
• Share to Skin and Cellular Biology Research
• Share to Systemic Sclerosis and Related Diseases