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Article

Decreased secretion of MMP by non-lesional late-stage scleroderma fibroblasts after selection via activation of the apoptotic Fas-pathway.

Journal of cellular physiology - 1 Jul 2011

Chabaud Stéphane, Corriveau Marie-Pier, Grodzicky Tamara, Senécal Jean-Luc, Chartier Suzanne, Raymond Yves, Moulin Véronique J

Abstract excerpt

Our hypothesis is that the development of lesional areas of skin in patients with systemic sclerosis (SSc) originates from the selection of profibrotic cell subpopulations within their non-lesional skin areas, due to their greater resistance to apoptosis. Sensitivity to apoptosis of early-stage or late-stage SSc fibroblasts as well as of healthy cells was compared using extrinsic or intrinsic apoptotic...

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Identifiers

PMID: 21506121
DOI: 10.1002/jcp.22520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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