Article
[The quantitative testing of V617F mutation in gen JAK2 using pyrosequencing technique].
Klinicheskaia laboratornaia diagnostika - 1 Nov 2014
Dunaeva E A, Mironov K O, Dribnokhodova T E, Subbotina E E, Bashmakova, Ol'hovskiĭ I A, Shipulin G A
Abstract excerpt
The somatic mutation V617F in gen JAK2 is a frequent cause of chronic myeloprolific diseases not conditioned by BCR/ABL mutation. The quantitative testing of relative percentage of mutant allele can be used in establishing severity of disease and its prognosis and in prescription of remedy inhibiting activity of JAK2. To quantitatively test mutation the pyrosequencing technique was applied. The developed...
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