Article
SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations.
Bioscience, biotechnology, and biochemistry - 1 Jan 2015
Okano Akira, Wan Kun, Kanda Kazuhiro, Yabuki Yukari, Funato Kouichi, Mizuta Keiko
Abstract excerpt
Ebp2 is an assembly factor of the 60S ribosomal subunit in yeast. We demonstrate that overexpression of SMY2 or SYH1 partially suppresses defects in growth and ribosome biogenesis of ebp2 mutants, and that smy2Δ and syh1Δ exhibit synthetic growth defects with the ebp2 allele. These results suggest that Smy2 and Syh1 may be involved in ribosome biogenesis in relation to Ebp2.
Topics
- Carrier Proteins
- Mutation
- RNA, Ribosomal
- Ribosomal Proteins
- Ribosome Subunits, Large, Eukaryotic
- Ribosomes
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Vesicular Transport Proteins