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Article

Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae.

Nucleic acids research - 1 May 2012

Shimoji Kaori, Jakovljevic Jelena, Tsuchihashi Kanako, Umeki Yuka, Wan Kun, Kawasaki Suzuka, Talkish Jason, Woolford John L, Mizuta Keiko

Abstract excerpt

The yeast protein Ebp2 is required for early steps in production of 60S ribosomal subunits. To search for cofactors with which Ebp2 functions, or substrates on which it acts, we screened for mutants that were synthetically lethal (sl) with the ebp2-14 mutation. Four different mutant alleles of the 60S ribosomal subunit assembly factor Brx1 were found. To investigate defects of the double mutant, we constructed...

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Identifiers

PMID: 22319211
DOI: 10.1093/nar/gks057
PMCID: PMC3378894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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