Article
Roles of Ebp2 and ribosomal protein L36 in ribosome biogenesis in Saccharomyces cerevisiae.
Current genetics - 1 Feb 2015
Wan Kun, Yabuki Yukari, Mizuta Keiko
Abstract excerpt
Ebp2 plays an essential role in biogenesis of 60S ribosomal subunits. We determined the genetic interactions between EBP2 and RPL36A/B, which encodes ribosomal protein L36a/b. RPL36A/B was a multicopy suppressor to ebp2 mutants, and the suppression was not common to defects in ribosome biogenesis resulting from other mutations of assembly factors. Disruption of RPL36A or RPL36B caused synthetic enhancement of the...
Topics
- Carrier Proteins
- Epistasis, Genetic
- Gene Expression
- Mutation
- RNA Precursors
- RNA, Ribosomal
- Ribosomal Proteins
- Ribosome Subunits, Large, Eukaryotic
- Ribosomes
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
