Article
Gene4Denovo: an integrated database and analytic platform for de novo mutations in humans.
Nucleic acids research - 8 Jan 2020
Zhao Guihu, Li Kuokuo, Li Bin, Wang Zheng, Fang Zhenghuan, Wang Xiaomeng, Zhang Yi, Luo Tengfei, Zhou Qiao, Wang Lin, Xie Yali, Wang Yijing, Chen Qian, Xia Lu, Tang Yu, Tang Beisha, Xia Kun, Li Jinchen
Abstract excerpt
De novo mutations (DNMs) significantly contribute to sporadic diseases, particularly in neuropsychiatric disorders. Whole-exome sequencing (WES) and whole-genome sequencing (WGS) provide effective methods for detecting DNMs and prioritizing candidate genes. However, it remains a challenge for scientists, clinicians, and biologists to conveniently access and analyse data regarding DNMs and candidate genes from...
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