Article
Sialyltransferases with enhanced legionaminic acid transferase activity for the preparation of analogs of sialoglycoconjugates.
Glycobiology - 1 Jul 2015
Watson David C, Wakarchuk Warren W, Leclerc Sonia, Schur Melissa J, Schoenhofen Ian C, Young N Martin, Gilbert Michel
Abstract excerpt
Legionaminic acids (Leg) are bacterial analogs of neuraminic acid, with the same stereochemistry but different substituents at C5, C7 and C9. Hence they may be incorporated into useful analogs of sialoglycoconjugates, and we previously reported two sialyltransferases that could utilize cytidine monophosphate (CMP)-Leg5Ac7Ac for preparation of Leg glycoconjugates, which were resistant to sialidases [Watson DC,...
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