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A Photobacterium sp. α2-6-sialyltransferase (Psp2,6ST) mutant with an increased expression level and improved activities in sialylating Tn antigens.

Carbohydrate research - 18 May 2015

Ding Li, Zhao Chao, Qu Jingyao, Li Yanhong, Sugiarto Go, Yu Hai, Wang Junru, Chen Xi

Abstract excerpt

In order to improve the catalytic efficiency of recombinant Photobacterium sp. JT-ISH-224 α2-6-sialyltransferase Psp2,6ST(15-501)-His6 in sialylating α-GalNAc-containing acceptors for the synthesis of tumor-associated carbohydrate antigens sialyl Tn (STn), protein crystal structure-based mutagenesis studies were carried out. Among several mutants obtained by altering the residues close to the acceptor substrate...

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Identifiers

PMID: 25593075
DOI: 10.1016/j.carres.2014.12.007
PMCID: PMC9416874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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