Article
Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants.
Haematologica - 1 Aug 2015
Agathanggelou Angelo, Weston Victoria J, Perry Tracey, Davies Nicholas J, Skowronska Anna, Payne Daniel T, Fossey John S, Oldreive Ceri E, Wei Wenbin, Pratt Guy, Parry Helen, Oscier David, Coles Steve J, Hole Paul S, Darley Richard L, McMahon Michael, Hayes John D, Moss Paul, Stewart Grant S, Taylor A Malcolm R, Stankovic Tatjana
Abstract excerpt
Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are required to target Ataxia Telangiectasia Mutated-deficient ch...
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