Article
Association between ankylosing spondylitis and the miR-146a and miR-499 polymorphisms.
PloS one - 1 Jan 2015
Xu Hui Ying, Wang Zhang Yang, Chen Jing Feng, Wang Tian Yang, Wang Ling Ling, Tang Li Li, Lin Xian-yang, Zhang Chun-wu, Chen Bi-cheng
Abstract excerpt
miRNAs are small, non-coding RNAs that regulate the expression of multiple target genes at the post-transcriptional level. Single-nucleotide polymorphisms (SNPs) in miRNA sequences may alter miRNA expression and have been implicated in the pathogenesis of multiple forms of arthritis, including rheumatoid arthritis (RA) and osteoarthritis. The present study explored the association between ankylosing spondylitis...
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