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Article

Three Polymorphisms of Vascular Endothelial Growth Factor (+936C > T, -460C > T, and -2578C > A) and Their Susceptibility to Ovarian Cancer: A Meta-Analysis.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jun 2015

Zhang Xiaolian, Qin Jinchun, Qin Aiping

Abstract excerpt

OBJECTIVE: Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen that plays a vital role in angiogenesis, tumor growth, and metastasis. The associations between 3 polymorphisms of VEGF (+936 C > T, -2578 C > A, and -460 C > T) and ovarian cancer (OC) risk have been extensively investigated, but the currently available results are inconsistent. To obtain a more accurate estimation of the...

Topics

Case-Control Studies
Female
Genetic Predisposition to Disease
Humans
Ovarian Neoplasms
Polymorphism, Genetic
Prognosis
Risk Factors
Vascular Endothelial Growth Factor A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25835351
DOI: 10.1097/IGC.0000000000000439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25835351-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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