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Article

A novel lamin A/C gene missense mutation (445 V > E) in immunoglobulin-like fold associated with left ventricular non-compaction.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 1 Apr 2016

Liu Zhouying, Shan Hong, Huang Jian, Li Ning, Hou Cuihong, Pu Jielin

Abstract excerpt

AIMS: Two LMNA mutations (R644C and R190W) have been associated with familial and sporadic left ventricular non-compaction (LVNC). However, the mechanisms underlying these associations have not been elucidated. METHODS AND RESULTS: Genomic DNA was isolated from peripheral blood leucocytes and analysed by direct sequencing. Human embryonic kidney 293 cells were transfected with either wild type or mutant LMNA and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isolated Noncompaction of the Ventricular Myocardium

Share to Lamin Type A

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Share to Protein Conformation, beta-Strand

Share to Tachycardia, Ventricular

Share to Ventricular Fibrillation

Source

Identifiers

PMID: 25829471
DOI: 10.1093/europace/euv044

Genes

LMNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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