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Article

Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference

30 Mar 2015

Abstract excerpt

The protein synthesis machineries of two distinct phyla of the Animal kingdom, insects of Arthropoda and mammals of Chordata, have different preferences for how to best encode proteins. Nevertheless, arboviruses (arthropod-borne viruses) are capable of infecting both mammals and insects just like arboviruses that use insect vectors to infect plants. These organisms have evolved carefully balanced genomes that can...

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PMID: 25825721
DOI: 10.1073/pnas.1502864112

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