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Article

Histomorphologic and molecular phenotypes predict gemcitabine response and overall survival in adenocarcinoma of the ampulla of Vater.

Surgery - 1 Jul 2015

Schiergens Tobias S, Reu Simone, Neumann Jens, Renz Bernhard W, Niess Hanno, Boeck Stefan, Heinemann Volker, Bruns Christiane J, Jauch Karl-Walter, Kleespies Axel

Abstract excerpt

BACKGROUND: The need for adjuvant chemotherapy after resection of ampullary cancer (PapCa) remains undefined. Recent data suggest that a different epithelial origin of PapCa might be associated with different tumor biology. The aim of the present study was to assess the clinical value of morphologic and immunohistochemic subclassification of PapCa into intestinal-type (IT) and pancreaticobiliary-type (PT) to...

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Source

Identifiers

PMID: 25819575
DOI: 10.1016/j.surg.2015.02.001

Genes

MUC2
CDX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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