Article
Genetic polymorphism of KIR2DL4 in the Polish population.
Tissue antigens - 1 Jun 2015
Nowak I, Barcz E, Majorczyk E, Malinowski A, Wilczyński J R, Banasik M, Motak-Pochrzęst H, Kuśnierczyk P
Abstract excerpt
The KIR2DL4 gene is characterized by alleles with either 9 or 10 consecutive adenines in exon 7, which encodes the transmembrane domain. The 9A variant produces either a protein with a truncated cytoplasmic tail or one lacking the transmembrane region. This causes a lack of KIR2DL4 expression. In contrast, 10A alleles encode receptors that may be expressed at the cell surface. We tested 438 healthy individuals...
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