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Simple, rapid and accurate molecular diagnosis of acute promyelocytic leukemia by loop mediated amplification technology

27 Dec 2014

Abstract excerpt

The diagnostic work-up of acute promyelocytic leukemia (APL) includes the cytogenetic demonstration of the t(15;17) translocation and/or the PML-RARA chimeric transcript by RQ-PCR or RT-PCR. This latter assays provide suitable results in 3-6 hours. We describe here two new, rapid and specific assays that detect PML-RARA transcripts, based on the RT-QLAMP (Reverse Transcription-Quenching Loop-mediated Isothermal...

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PMID: 25815362
DOI: 10.18632/oncoscience.114

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