Article
Improved pharmacodynamics and pharmacokinetics after i.v. application of peginterferon alfa-2a in hepatitis C null responders.
Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2015
Fülöp Balazs, Biermer Michael, Cornberg Markus, Wedemeyer Heiner, Port Kerstin, Heyne Renate, Zeuzem Stefan, Peiffer Kai-Henrik, Welzel Tania, Herber Adam, Buggisch Peter, Moser Christoph, Stoll Sabine, Alshuth Ulrich, Berg Thomas
Abstract excerpt
BACKGROUND & AIM: Mechanisms of non-responsiveness to peginterferon alfa-2a are not completely understood. Inadequate plasma levels may contribute to reduced response. The aim of this prospective, multicentre, crossover, Phase 1 study was to evaluate the pharmacokinetics and viral kinetics of intravenous vs. subcutaneous peginterferon alfa-2a in patients with genotype 1 chronic hepatitis C infection who showed...
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