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Article

YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence.

Oncotarget - 10 Apr 2015

Sheridan Christine Moore, Grogan Tristan R, Nguyen Hao G, Galet Colette, Rettig Matthew B, Hsieh Andrew C, Ruggero Davide

Abstract excerpt

Attempts to identify biomarkers to detect prostate tumorigenesis, and thus minimize prostate cancer progression and inform treatment decisions have primarily focused on alterations at the DNA and mRNA levels, ignoring alterations at the level of protein synthesis control. We have previously shown that the PI3K-AKT-mTOR pathway, frequently deregulated in prostate cancer, specifically induces the synthesis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25797255
DOI: 10.18632/oncotarget.3477
PMCID: PMC4480693

Genes

MTA1

Provenance

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