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High Throughput Measurement of γH2AX DSB Repair Kinetics in a Healthy Human Population

20 Mar 2015

Abstract excerpt

The Columbia University RABiT (Rapid Automated Biodosimetry Tool) quantifies DNA damage using fingerstick volumes of blood. One RABiT protocol quantifies the total γ-H2AX fluorescence per nucleus, a measure of DNA double strand breaks (DSB) by an immunofluorescent assay at a single time point. Using the recently extended RABiT system, that assays the γ-H2AX repair kinetics at multiple time points, the present...

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PMID: 25794041
DOI: 10.1371/journal.pone.0121083

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