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Article

Evolutionary insights into host-pathogen interactions from mammalian sequence data.

Nature reviews. Genetics - 1 Apr 2015

Sironi Manuela, Cagliani Rachele, Forni Diego, Clerici Mario

Abstract excerpt

Infections are one of the major selective pressures acting on humans, and host-pathogen interactions contribute to shaping the genetic diversity of both organisms. Evolutionary genomic studies take advantage of experiments that natural selection has been performing over millennia. In particular, inter-species comparative genomic analyses can highlight the genetic determinants of infection susceptibility or...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Genetic Variation
Genomics
Host-Pathogen Interactions
Humans
Mammals
Molecular Sequence Data
Sequence Analysis, DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Amino Acid

Sequence Homology, Nucleic Acid

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Identifiers

PMID: 25783448
DOI: 10.1038/nrg3905
PMCID: PMC7096838

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