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Article

Local control after stereotactic radiosurgery for brain metastases in patients with melanoma with and without BRAF mutation and treatment.

Journal of neurosurgery - 1 Aug 2015

Ly David, Bagshaw Hilary P, Anker Christopher J, Tward Jonathan D, Grossmann Kenneth F, Jensen Randy L, Shrieve Dennis C

Abstract excerpt

OBJECT: BRAF inhibitors improve progression-free and overall survival in patients with metastatic melanoma. Brain metastases are common, and stereotactic radiosurgery (SRS) has been used, resulting in excellent local control. Because BRAF inhibitors are associated with intracranial responses, the authors hypothesized that BRAF inhibitors would improve local control in patients with melanoma who are receiving SRS...

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Source

Identifiers

PMID: 25768829
DOI: 10.3171/2014.9.JNS141425

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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