Wiring for independence: positive feedback motifs facilitate individuation of traits in development and evolution.

Abstract excerpt

Independent selection response of a trait is contingent on the availability of genetic variation that is not entangled with other traits. Mechanistically, such variational individuation in spite of shared genome results from gene regulation. Changes that increase individuation of traits are likely caused by gene regulatory changes. Yet the effect of regulatory evolution on population variation is understudied....

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