Article
Utility of the multivariate approach in predicting β-thalassemia intermedia or β-thalassemia major types In Iranian patients.
Hemoglobin - 1 Jan 2013
Banan Mehdi, Bayat Hadi, Namdar-Aligoodarzi Pegah, Azarkeivan Azita, Kamali Koorosh, Daneshmand Parvaneh, Zaker-Kandjani Behzad, Najmabadi Hossein
Abstract excerpt
Recently, five genetic modifiers [β-globin mutations, coinheritance of α-thalassemia (α-thal), XmnI polymorphism and single nucleotide polymorphisms (SNPs) in the BCL11A and HBS1L-MYB loci] were used to predict the β-thal major (β-TM) or β-thal intermedia (β-TI) types in 106 French patients with 83.2% accuracy. The dichotomous grouping was based on the age when the patient received his/her first transfusion (4...
Topics
- Adult
- Binding Sites
- Carrier Proteins
- Cohort Studies
- DNA, Intergenic
- Deoxyribonucleases, Type II Site-Specific
- Female
- GTP-Binding Proteins
- Gene Frequency
- Genotype
- HSP70 Heat-Shock Proteins
- Humans
- Iran