Article
Two distinct truncated apolipoprotein B species in a kindred with hypobetalipoproteinemia.
Arteriosclerosis (Dallas, Tex.) - 1 Jan 2000
Krul E S, Kinoshita M, Talmud P, Humphries S E, Turner S, Goldberg A C, Cook K, Boerwinkle E, Schonfeld G
Abstract excerpt
Two novel, distinct truncated forms of apolipoprotein B (apo B) designated as apo B-90 and apo B-40 were found in five members of a kindred with hypobetalipoproteinemia. Sodium dodecyl sulfate gels and immunoblots of plasma or low density lipoprotein (LDL) (d = 1.019 to 1.063 g/ml) of the affected members demonstrated the presence of one or both of the truncated apo B bands. Employing four monoclonal anti-LDL...
Topics
- Antibodies, Monoclonal
- Apolipoproteins B
- Cholesterol
- Chromatography, High Pressure Liquid
- Humans
- Hypobetalipoproteinemias
- Hypolipoproteinemias
- Lipoproteins, LDL
- Mutation
- Pedigree