Article
Isozyme-specific monoclonal antibody-directed assessment of induction of hepatic cytochrome p-450 by clotrimazole.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Khan W A, Kuhn C, Merk H F, Park S S, Gelboin H V, Bickers D R, Mukhtar H
Abstract excerpt
Clotrimazole, an N-substituted imidazole widely used as an antifungal agent, has been shown to both inhibit and induce hepatic cytochrome P-450 and related monooxygenase activities. In this study the profile of hepatic cytochrome P-450 isozyme(s) induced by clotrimazole treatment of male Sprague-Dawley rats was investigated. Clotrimazole administration (100 mg/kg, daily for 4 days, ig) resulted in 86% induction...
Topics
- Animals
- Antibodies, Monoclonal
- Clotrimazole
- Cytochrome P-450 Enzyme System
- Electrophoresis, Polyacrylamide Gel
- Enzyme Induction
- Imidazoles
- In Vitro Techniques
- Isoenzymes
- Liver