Article
A high-resolution genomic analysis of multidrug-resistant hospital outbreaks of Klebsiella pneumoniae.
EMBO molecular medicine - 1 Mar 2015
Chung The Hao, Karkey Abhilasha, Pham Thanh Duy, Boinett Christine J, Cain Amy K, Ellington Matthew, Baker Kate S, Dongol Sabina, Thompson Corinne, Harris Simon R, Jombart Thibaut, Le Thi Phuong Tu, Tran Do Hoang Nhu, Ha Thanh Tuyen, Shretha Shrijana, Joshi Suchita, Basnyat Buddha, Thwaites Guy, Thomson Nicholas R, Rabaa Maia A, Baker Stephen
Abstract excerpt
Multidrug-resistant (MDR) Klebsiella pneumoniae has become a leading cause of nosocomial infections worldwide. Despite its prominence, little is known about the genetic diversity of K. pneumoniae in resource-poor hospital settings. Through whole-genome sequencing (WGS), we reconstructed an outbreak of MDR K. pneumoniae occurring on high-dependency wards in a hospital in Kathmandu during 2012 with a case-fatality...
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