Article
A generic assay for whole-genome amplification and deep sequencing of enterovirus A71.
Journal of virological methods - 1 Apr 2015
Tan Le Van, Tuyen Nguyen Thi Kim, Thanh Tran Tan, Ngan Tran Thuy, Van Hoang Minh Tu, Sabanathan Saraswathy, Van Tran Thi My, Thanh Le Thi My, Nguyet Lam Anh, Geoghegan Jemma L, Ong Kien Chai, Perera David, Hang Vu Thi Ty, Ny Nguyen Thi Han, Anh Nguyen To, Ha Do Quang, Qui Phan Tu, Viet Do Chau, Tuan Ha Manh, Wong Kum Thong, Holmes Edward C, Chau Nguyen Van Vinh, Thwaites Guy, van Doorn H Rogier
Abstract excerpt
Enterovirus A71 (EV-A71) has emerged as the most important cause of large outbreaks of severe and sometimes fatal hand, foot and mouth disease (HFMD) across the Asia-Pacific region. EV-A71 outbreaks have been associated with (sub)genogroup switches, sometimes accompanied by recombination events. Understanding EV-A71 population dynamics is therefore essential for understanding this emerging infection, and may...
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