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Article

Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation.

Human molecular genetics - 1 Jan 2015

Yu Wanfeng, He Xin, Ni Ying, Ngeow Joanne, Eng Charis

Abstract excerpt

Germline mutations in the PTEN tumor-suppressor gene and germline variations in succinate dehydrogenase subunit D gene (SDHD-G12S, SDHD-H50R) are associated with a subset of Cowden syndrome and Cowden syndrome-like individuals (CS/CSL) and confer high risk of breast, thyroid and other cancers. Ho...

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Source

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Identifiers

PMID: 25149476
DOI: 10.1093/hmg/ddu425
PMCID: PMC4262496

Genes

SDHD
PTEN
SRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25149476-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation.PMID 25149476Read ↗

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