Effects of 49 Different Rare Hb Variants on HbA1c Measurement in Eight Methods.

doi:10.1177/1932296815572367

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Article

Effects of 49 Different Rare Hb Variants on HbA1c Measurement in Eight Methods.

Journal of diabetes science and technology - 1 Jul 2015

Little Randie R, La'ulu Sonia L, Hanson Steven E, Rohlfing Curt L, Schmidt Robert L

Abstract excerpt

BACKGROUND: Previous studies have shown interference with HbA1c measurement from the 4 most common heterozygous Hb variants (HbAS, HbAE, HbAC, and HbAD) with some assay methods. Here we examine analytical interference from 49 different less common variants with 7 different HbA1c methods using various method principles. METHODS: Hb variants were screened using the Bio-Rad Variant or Variant II beta thal short...

Topics

Chromatography, High Pressure Liquid
Electrophoresis
Genetic Variation
Glycated Hemoglobin
Hemoglobins, Abnormal
Heterozygote
Humans
Immunoassay
Linear Models
Reproducibility of Results
Sequence Analysis, DNA

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Identifiers

PMID: 25691657
DOI: 10.1177/1932296815572367
PMCID: PMC4525651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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