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Article

The active site of yeast phosphatidylinositol synthase Pis1 is facing the cytosol.

Biochimica et biophysica acta - 1 May 2015

Bochud Arlette, Conzelmann Andreas

Abstract excerpt

Five yeast enzymes synthesizing various glycerophospholipids belong to the CDP-alcohol phosphatidyltransferase (CAPT) superfamily. They only share the so-called CAPT motif, which forms the active site of all these enzymes. Bioinformatic tools predict the CAPT motif of phosphatidylinositol synthase Pis1 as either ER luminal or cytosolic. To investigate the membrane topology of Pis1, unique cysteine residues were...

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Identifiers

PMID: 25687304
DOI: 10.1016/j.bbalip.2015.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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