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CYP2B6 genetic variation in cyclophosphamide metabolism and hemorrhagic cystitis in Fanconi anemia patients undergoing allogeneic hematopoietic cell transplantation

2023-01-24

Abstract excerpt

<title>Abstract</title> <p>Background Fanconi anemia (FA) is an inherited disorder characterized by congenital malformations, bone marrow failure and malignancies. Hematopoietic cell transplant (HCT) is the only proven cure for the hematological complications. FA patients have increased chromosomal instability and aberrant DNA repair and thus can only tolerate low doses of chemotherapy or radiation as part of co...

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Literature Corpus work
d536b4da-ec22-5cb0-ace1-3a8b071144dc
DOI
10.21203/rs.3.rs-1428660/v1
Open publication

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