Article
Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression.
Human molecular genetics - 1 Aug 2013
Kanagawa Motoi, Yu Chih-Chieh, Ito Chiyomi, Fukada So-ichiro, Hozoji-Inada Masako, Chiyo Tomoko, Kuga Atsushi, Matsuo Megumi, Sato Kanoko, Yamaguchi Masahiko, Ito Takahito, Ohtsuka Yoshihisa, Katanosaka Yuki, Miyagoe-Suzuki Yuko, Naruse Keiji, Kobayashi Kazuhiro, Okada Takashi, Takeda Shin'ichi, Toda Tatsushi
Abstract excerpt
A group of muscular dystrophies, dystroglycanopathy is caused by abnormalities in post-translational modifications of dystroglycan (DG). To understand better the pathophysiological roles of DG modification and to establish effective clinical treatment for dystroglycanopathy, we here generated two distinct conditional knock-out (cKO) mice for fukutin, the first dystroglycanopathy gene identified for Fukuyama...
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