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Article

Evolution of simeprevir-resistant variants in virological non-responders infected with HCV genotype 1b.

Journal of medical virology - 1 Apr 2015

Akuta Norio, Suzuki Fumitaka, Sezaki Hitomi, Hosaka Tetsuya, Kobayashi Masahiro, Suzuki Yoshiyuki, Saitoh Satoshi, Kobayashi Mariko, Ikeda Kenji, Kumada Hiromitsu

Abstract excerpt

The present study was designed to assess the evolution of simeprevir-resistant variants (amino acid substitutions of aa80, aa155, aa156, and aa168 positions in HCV NS3 region) over time in virological non-responders (patients with positive HCV-RNA during and at end of treatment). The study enrolled 136 patients infected with HCV genotype 1b who received 12-week simeprevir-PEG-IFN-ribavirin therapy, and data of 87...

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Share to Hepatitis C, Chronic
Share to Heterocyclic Compounds, 3-Ring

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-alpha

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Identifiers

PMID: 25655809
DOI: 10.1002/jmv.24113

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