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Article

Unexpected Replication Boost by Simeprevir for Simeprevir-Resistant Variants in Genotype 1a Hepatitis C Virus.

Antimicrobial agents and chemotherapy - 1 Jul 2018

Murai Kazuhisa, Shimakami Tetsuro, Welsch Christoph, Shirasaki Takayoshi, Liu Fanwei, Kitabayashi Juria, Tanaka Shiho, Funaki Masaya, Omura Hitoshi, Nishikawa Tomoki, Sumiyadorj Ariunaa, Honda Masao, Kaneko Shuichi

Abstract excerpt

Simeprevir is a novel NS3/4A protease inhibitor (PI) of hepatitis C virus (HCV). The baseline polymorphism NS3-Q80K is frequently observed in genotype (GT) 1a HCV and often associated with treatment failure in simeprevir-containing regimens. We aimed to elucidate mechanisms of treatment failure due to NS3-Q80K. We included a Q80R mutation in our study and generated a series of Huh-7.5 cell lines, each of which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29661883
DOI: 10.1128/AAC.02601-17
PMCID: PMC6021633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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