Article
Emergence of resistance-associated variants after failed triple therapy with vaniprevir in treatment-experienced non-cirrhotic patients with hepatitis C-genotype 1 infection: a population and clonal analysis.
Virology - 1 Sept 2013
Barnard Richard J O, McHale Carolyn M, Newhard William, Cheney Carol A, Graham Donald J, Himmelberger Amy L, Strizki Julie, Hwang Peggy M T, Rivera Amber A, Reeves Jacqueline D, Nickle David, Dinubile Mark J, Hazuda Daria J, Mobashery Niloufar
Abstract excerpt
BACKGROUND: Vaniprevir with P/R improved SVR rates over P/R alone in treatment-experienced patients with chronic HCV-genotype 1 infection, but treatment failure presents therapeutic challenges. We identified RAVs from non-cirrhotic patients failing to achieve SVR on vaniprevir-containing regimens from a dose/duration-ranging trial of triple-combination therapy. METHODS: Using population analysis, resistance...
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