Article
Identification of an interaction between VWF rs7965413 and platelet count as a novel risk marker for metabolic syndrome: an extensive search of candidate polymorphisms in a case-control study.
PloS one - 1 Jan 2015
Nakatochi Masahiro, Ushida Yasunori, Yasuda Yoshinari, Yoshida Yasuko, Kawai Shun, Kato Ryuji, Nakashima Toru, Iwata Masamitsu, Kuwatsuka Yachiyo, Ando Masahiko, Hamajima Nobuyuki, Kondo Takaaki, Oda Hiroaki, Hayashi Mutsuharu, Kato Sawako, Yamaguchi Makoto, Maruyama Shoichi, Matsuo Seiichi, Honda Hiroyuki
Abstract excerpt
Although many single nucleotide polymorphisms (SNPs) have been identified to be associated with metabolic syndrome (MetS), there was only a slight improvement in the ability to predict future MetS by the simply addition of SNPs to clinical risk markers. To improve the ability to predict future MetS, combinational effects, such as SNP-SNP interaction, SNP-environment interaction, and SNP-clinical parameter (SNP ×...
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