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Data-Driven Asthma Endotypes Defined from Blood Biomarker and Gene Expression Data

2 Feb 2015

Abstract excerpt

The diagnosis and treatment of childhood asthma is complicated by its mechanistically distinct subtypes (endotypes) driven by genetic susceptibility and modulating environmental factors. Clinical biomarkers and blood gene expression were collected from a stratified, cross-sectional study of asthmatic and non-asthmatic children from Detroit, MI. This study describes four distinct asthma endotypes identified via a...

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PMID: 25643280
DOI: 10.1371/journal.pone.0117445

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