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Article

Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold.

Journal of medicinal chemistry - 12 Jun 2008

Niculescu-Duvaz Ion, Roman Esteban, Whittaker Steven R, Friedlos Frank, Kirk Ruth, Scanlon Ian J, Davies Lawrence C, Niculescu-Duvaz Dan, Marais Richard, Springer Caroline J

Abstract excerpt

BRAF, a serine/threonine kinase, plays a key role in the development of certain types of cancer, particularly melanoma. 2-(3,4,5-Trimethoxyphenylamino)-6-(3-acetamidophenyl)-pyrazine, 1, was identified as a low micromolar (IC 50 = 3.5 microM) BRAF inhibitor from a high-throughput screen of a library of 23000 compounds. This compound was chosen as the starting point of a program aimed at developing inhibitors of...

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PMID: 18473434
DOI: 10.1021/jm070776b

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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