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Article

Evolution of BCR/ABL gene mutation in CML is time dependent and dependent on the pressure exerted by tyrosine kinase inhibitor.

PloS one - 1 Jan 2015

Vaidya Shantashri, Vundinti Babu Rao, Shanmukhaiah Chandrakala, Chakrabarti Prantar, Ghosh Kanjaksha

Abstract excerpt

BACKGROUND: Mutations in the ABL kinase domain and SH3-SH2 domain of the BCR/ABL gene and amplification of the Philadelphia chromosome are the two important BCR/ABL dependent mechanisms of imatinib resistance. Here, we intended to study the role played by TKI, imatinib, in selection of gene mutat...

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Share to Chromosome Duplication
Share to Fusion Proteins, bcr-abl
Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation Rate

Share to Neoplasm Staging

Share to Protein Interaction Domains and Motifs

Share to Protein Kinase Inhibitors

Share to src Homology Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 25629972
DOI: 10.1371/journal.pone.0114828
PMCID: PMC4309587

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25629972-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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