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Article

NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma.

International journal of cancer - 15 Aug 2015

Zhang Zhuang-Zhuang, Huang Jian, Wang Yu-Ping, Cai Bing, Han Ze-Guang

Abstract excerpt

Oncogene activation or inactivation of tumor suppressor genes are crucial to tumor initiation and progression. DNA copy number amplification is one of many mechanisms that activate oncogenes in many tumors, including hepatocellular carcinoma (HCC). Although it has been known that some oncogenes such as c-myc amplification is involved in HCC pathogenesis, more oncogenes with DNA copy amplification contribute to...

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PMID: 25612832
DOI: 10.1002/ijc.29451

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