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Article

Restriction fragment length polymorphism effectively identifies exon 1 mutation of UGT1A1 gene in patients with Gilbert's Syndrome.

Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2015

Shiu Tzu-Yue, Huang Hsin-Hung, Lin Hsuan-Hwai, Shih Yu-Lueng, Chu Heng-Cheng, Chang Wei-Kuo, Hsieh Tsai-Yuan

Abstract excerpt

BACKGROUND & AIMS: Gilbert's syndrome causes pharmacological variation in drug glucuronidation and unexpected toxicity from therapeutic agents. The two common genotypes of Gilbert's syndrome are a dinucleotide polymorphism (TA)7 in TATA-Box as well as the 211G>A mutation in the coding exon 1, particularly in Asians, of human UGT1A1 gene. In this study, we aimed to establish an effective method to detect the...

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Identifiers

PMID: 25611851
DOI: 10.1111/liv.12785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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