Analysis of the ORFK1 hypervariable regions reveal distinct HHV-8 clustering in Kaposi's sarcoma and non-Kaposi's cases.

doi:10.1186/s13046-014-0119-0

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Article

Analysis of the ORFK1 hypervariable regions reveal distinct HHV-8 clustering in Kaposi's sarcoma and non-Kaposi's cases.

Journal of experimental & clinical cancer research : CR - 16 Jan 2015

Cordiali-Fei Paola, Trento Elisabetta, Giovanetti Marta, Lo Presti Alessandra, Latini Alessandra, Giuliani Massimo, D'Agosto Giovanna, Bordignon Valentina, Cella Eleonora, Farchi Francesca, Ferraro Carmela, Lesnoni La Parola Ilaria, Cota Carlo, Sperduti Isabella, Vento Antonella, Cristaudo Antonio, Ciccozzi Massimo, Ensoli Fabrizio

Abstract excerpt

BACKGROUND: Classical Kaposi's Sarcoma (cKS) is a rare vascular tumor, which develops in subjects infected with Human Herpesvirus-8 (HHV-8). Beside the host predisposing factors, viral genetic variants might possibly be related to disease development. The aim of this study was to identify HHV-8 variants in patients with cKS or in HHV-8 infected subjects either asymptomatic or with cKS-unrelated cutaneous...

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PMID: 25592960
DOI: 10.1186/s13046-014-0119-0
PMCID: PMC4311464

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