Article
An integrated framework for reporting clinically relevant biomarkers from paired tumor/normal genomic and transcriptomic sequencing data in support of clinical trials in personalized medicine.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2015
Nasser Sara, Kurdolgu Ahmet A, Izatt Tyler, Aldrich Jessica, Russell Megan L, Christoforides Alexis, Tembe Wiabhav, Keifer Jeffery A, Corneveaux Jason J, Byron Sara A, Forman Karen M, Zuccaro Clarice, Keats Jonathan J, Lorusso Patricia M, Carpten John D, Trent Jeffrey M, Craig David W
Abstract excerpt
The ability to rapidly sequence the tumor and germline DNA of an individual holds the eventual promise of revolutionizing our ability to match targeted therapies to tumors harboring the associated genetic biomarkers. Analyzing high throughput genomic data consisting of millions of base pairs and discovering alterations in clinically actionable genes in a structured and real time manner is at the crux of...
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