Article
Diazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes.
Diabetes - 1 Jun 2015
George Priya S, Tavendale Roger, Palmer Colin N A, McCrimmon Rory J
Abstract excerpt
Individuals with long-standing type 1 diabetes (T1D) are at increased risk of severe hypoglycemia secondary to impairments in normal glucose counterregulatory responses (CRRs). Strategies to prevent hypoglycemia are often ineffective, highlighting the need for novel therapies. ATP-sensitive potassium (KATP) channels within the hypothalamus are thought to be integral to hypoglycemia detection and initiation of...
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