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Article

Evidence for a dualistic model of high-grade serous carcinoma: BRCA mutation status, histology, and tubal intraepithelial carcinoma.

The American journal of surgical pathology - 1 Mar 2015

Howitt Brooke E, Hanamornroongruang Suchanan, Lin Douglas I, Conner James E, Schulte Stephanie, Horowitz Neil, Crum Christopher P, Meserve Emily E

Abstract excerpt

Most early adnexal carcinomas detected in asymptomatic women with germline BRCA mutations (BRCA) present as serous tubal intraepithelial carcinomas (STIC). However, STICs are found in only ∼40% of symptomatic high-grade serous carcinomas (HGSCs) and less frequently in pseudoendometrioid variants of HGSC. Consecutive cases of untreated HGSC from BRCA and BRCA women with detailed fallopian tube examination (SEE-FIM...

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PMID: 25581732
DOI: 10.1097/PAS.0000000000000369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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