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Article

Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation

9 Jan 2015

Abstract excerpt

Resilience to host inflammation and other perturbations is a fundamental property of gut microbial communities, yet the underlying mechanisms are not well understood. We have found that human gut microbes from all dominant phyla are resistant to high levels of inflammation-associated antimicrobial peptides (AMPs) and have identified a mechanism for lipopolysaccharide (LPS) modification in the phylum Bacteroidetes...

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PMID: 25574022
DOI: 10.1126/science.1260580

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