Article
Elevated mutation rate during meiosis in Saccharomyces cerevisiae.
PLoS genetics - 1 Jan 2015
Rattray Alison, Santoyo Gustavo, Shafer Brenda, Strathern Jeffrey N
Abstract excerpt
Mutations accumulate during all stages of growth, but only germ line mutations contribute to evolution. While meiosis contributes to evolution by reassortment of parental alleles, we show here that the process itself is inherently mutagenic. We have previously shown that the DNA synthesis associated with repair of a double-strand break is about 1000-fold less accurate than S-phase synthesis. Since the process of...
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