Article
The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance.
The Journal of antimicrobial chemotherapy - 1 Oct 2014
Chong Huihui, Yao Xue, Qiu Zonglin, Sun Jianping, Qiao Yuanyuan, Zhang Meng, Wang Meitian, Cui Sheng, He Yuxian
Abstract excerpt
OBJECTIVES: Peptides derived from the C-terminal heptad repeat (CHR) of HIV-1 gp41 are potent fusion inhibitors. We have recently demonstrated that the unique M-T hook structure preceding the pocket-binding motif of CHR peptide-based inhibitors can greatly improve their antiviral activity. In this study, we applied the M-T hook structure to optimize sifuvirtide (SFT), a potent CHR-derived inhibitor currently...
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