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Article

Ribonucleotide reductase M1 (RRM1) 2464G>A polymorphism shows an association with gemcitabine chemosensitivity in cancer cell lines.

Pharmacogenetics and genomics - 1 Jun 2006

Kwon Woo Sun, Rha Sun Young, Choi Yeon Ho, Lee Jung Ok, Park Kyu Hyun, Jung Jae Joon, Kim Tae Soo, Jeung Hei-Cheul, Chung Hyun Cheol

Abstract excerpt

OBJECTIVES: Significant variability in the efficacy and toxicity of an anticancer drug is observed in cancer patients. Currently, there are no standard tools for prediction of a patient's tumor response or his risk of adverse events to chemotherapy. METHODS: We investigate an association between polymorphisms of gemcitabine metabolism-related genes and its chemosensitivity in vitro using 62 human cancer cell...

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Source

Identifiers

PMID: 16708051
DOI: 10.1097/01.fpc.0000204999.29924.da

Genes

RRM1
DCTD
DCK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Ribonucleotide reductase M1 (RRM1) 2464G>A polymorphism shows an association with gemcitabine chemosensitivity in cancer cell lines.PMID 16708051Read ↗

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